The 15th International Symposium of Information Science, a biannual conference for scholars, researchers, professionals and students in information science, takes place at Humboldt-Universität zu Berlin from 13 to 15 March 2017. This year’s theme of “Everything Changes, Everything Stays the Same? Understanding Information Spaces” puts the dynamic of the field of information and its applications in the center. With the ongoing digitization and virtualization of goods, services and living environments, information science reflects on the potential changes within the information society. While some parts of the community proclaim a revolutionary shift not only in the way we approach information and information systems, but also in the way society constitutes itself, others state that while the applications and interfaces adapt to advances in information technology, the underlying principles for human interactions with information remain the same. In the ISI 2017 proceedings, contributions on the development of innovative information spaces and services, on analyses of human-computer interactions in physical or virtual information spaces and on the role of information science and its research endeavors are included.