This book is written for the students and entrepreneurs who will want to understand the role and meaning of SMEs (Small Medium-Sized Enterprises) in the globalization. In all countries of the world are the most companies small and medium-sized, but in the public and political focus stand mostly the "big ones". This is inappropriate because of the real role of "sustainable, smart, innovative SMEs" of global. Experts from the "German Mittelstand", and International Sustainability Management has written this book which is oriented directly to Managers of Global SMEs. SMEs (Small Medium-Sized Enterprises) play an extremely important role in economic development through generating employment, growth in business marketing and improving economic situation, environmental sustainability through utilizing innovative, profitable and blue-green strategies aligned with water resources, environment and social development through using CSR's strategies to gain societal goals and creating innovative solutions to the challenges such as poverty, social exclusion and unemployment. Generally, SMEs could be used as a tool to deal with global challenges like environmental problems, economic challenges, social instability, poverty and etc. Therefore, SMEs could improve sustainable development in order to achieve high quality of life and livability (sustainability) in the world. In this book, rudiment concerned on SMEs is explored. In addition, roles of innovation, technologies, digitalization, and knowledgeable capital in achieving successful and sustainable SMEs in Industry 4.0 is attended. In particular, the main aim of the research is to achieve sustainability regarding to improve quality of life and livability through innovative, profitable, manageable strategies for Global SMEs. It is one of these books that you can implement into work right away. The authors writing will motivate you to move forward, because it will make you feel like everything you need to handle is easily manageable. This book will bridge the gap of knowledge and highlight the modern and effective findings related to the Global SMEs, innovation, digitalization, sustainability, HR, Industry 4.0, and multinational cooperation. The content teaches about specifics of Global SMEs. As further guidance, authors define what exactly a SMEs should contain and shares personal examples as well as models including all the required steps to reach the set goals. The book shows the most effective way of balancing the fundamental pillars, assisting the mod-ern day manager by handling a dynamic, constantly adjusting workplace, which easily adapts to all challenges and changes.