At the end of 2012 the Baltic Sea Region Programme initiated the cluster “Innovation in SMEs”, starting with ten projects that focused their work on this important topic. During 2013 three additional projects joined the initiative. Most projects are flagship projects within the EU Strategy for the Baltic Sea region, namely in Priority SME Networks, Innovation and Education. Maintaining a high level of innovative thinking and entrepreneurship is crucial for SMEs to stay competitive and allow growth in the region. This publication gives an short overview of the 13 projects that were implemented between 2010 and 2014. The projects participated in workshops and surveys to increase the mutual learning and share experience. The findings are summarized. In 2013 a survey was conducted to learn more about the status quo of “Innovation in SMEs” in the Baltic Sea Region and learn more about the relevant topics for the future. More than 600 stakeholders participated in the survey. The publication shows the most relevant questions and answers and draws the conclusions from the survey.