Artificial intelligence (AI) is rapidly being implemented in the healthcare sphere, threatening the ability of patients to make judgments tailored to their personal circumstances and beliefs. This book is concerned with the ability of two legal systems, those of the UK and the U.S., to meet the resulting challenges posed to patient autonomy. It deploys a forward-looking analysis to identify the unique problems raised by clinical AI and to anticipate the responses that are offered by the common law’s doctrine of informed consent. This assessment culminates in a concrete proposal for the regulation of medical AI and an affirmation of the law’s fundamental role in societies’ adaptation to innovative technologies.