The focus of this study is on Oecolampadius’s 1534 commentary on the biblical book of Hebrews, which derived from his theology lectures at the University of Basel in 1529-1530. Jeff Fisher compares his exegesis with more than twenty-five of the most relevant interpreters from the early church to the Reformation. He shows that by recovering and adapting an Alexandrian interpretive notion of Christ as the goal of Scripture, Oecolampadius’s Christoscopic reading of Scripture served as an essential step in the shift toward Reformed interpretative approaches, such as that of John Calvin.