Optimization of itaconic acid production by U. maydis through metabolic engineering & adaptive laboratory evolution

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Optimization of itaconic acid production by U. maydis through metabolic engineering & adaptive laboratory evolution
This thesis focused on the fungus Ustilago maydis as natural itaconic acid producer. Two strategies were chased to improve its production performance: metabolic engineering and adaptive laboratory evolution. The final engineered strains feature great, far optimized itaconate production parameters making U. maydis an industrial relevant production host for this value-added chemical from biomass.

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ISBN: 9783863597795

Language: English

Publication date: 20.12.2019

Number of pages: 148

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