The field of pediatric bone and soft tissue sarcomas has experienced a gradual but surprising transformation. Fundamental discoveries in the molecular biology of disease, recent breakthroughs in diagnostic imaging, and revolutionary surgical techniques have created unprecedented synergies and a refreshing vision with which to approach the diagnosis and treatment of these pediatric tumors. This book highlights the paths leading to the emergence of such a new vision and presents salient concepts in epidemiology, novel tools in imaging and molecular biology, and principles of drug development – as the scaffold to understanding the pathophysiology and treatment of pediatric sarcomas. The book provides an up-to-date comprehensive reference text that articulates a multidisciplinary approach for the diagnosis and treatment of each of these often challenging diseases.