The global CORONA crisis threatens our existence and exposes the fragile foundations upon which we have built life as we know it. The clear necessity of a rapid response has accelerated and strengthened our readiness to embrace CHANGE towards greater sustainability and a stable, hospitable future. In the spirit of advancing this multifaceted process of innovation, this volume presents the forward thinking of some ninety renowned representatives of science, industry, media and politics. We hope to inspire our readers to draw on the newfound abilities and experiences they have acquired over the past year to initiate transformation – be it in secondary and tertiary education, in private and professional communication, in production and sales in small or large companies. Let us sustain the courage to embrace well-founded scientific innovation without dragging our heels in extensive debate. Let us take the CHANCE before us now to change our world, for example, by taking the digital turn in education, healthcare, mobility and much more.